Testis-specific protein, Y encoded Tspy and Zfy are two other Y-associated genes that translocated to the distal part of the long arm of the X chromosome in the Amami spiny rat Arakawa et al. In various fish and reptiles, incubation temperature during a critical embryonic period results in male or female sexual differentiation, but this can be overridden in males by early exposure to estrogenic chemicals.
Prototherian mammals monotremes Mammals are comprised for two classification groups: therians, which includes placental mammals and marsupials and prototherians monotremes or egg-laying mammals. In this species, dmy might stimulate male sexual differentiation by increasing gonadal soma derived growth factor gsdf and sox9a2 but suppressing the expression of rspo1 Chakraborty et al.
To test further the role of SRY in regulating dopaminergic neurons, human male dopamine M17 cells were treated with a dopaminergic toxin, 6-hydroxydopamine 6-OHDAwhich resulted in a significant upregulation of SRY Czech et al. Neonatal mice possessing an Sry transgene show a masculinized pattern of progesterone receptor expression in the brain independent of sex chromosome status.
The multiple sex chromosomes of platypus and echidna are not completely identical and several share homology with the avian Z. X-chromosomal localization of mammalian Y-linked genes in two XO species of the Ryukyu spiny rat. However, the role of Sry in brain sexual differentiation is uncertain.
Two genes that might stimulate male gonad sexual differentiation in Amami spiny rats are Cbx2 and Er71 Kuroiwa et al. Steroid hormones at both periods may trigger epigenetic changes in various brain regions that underpin sex differences in brain responses Tsai et al.
Transcriptomic alterations in the brain of painted turtles Chrysemys picta developmentally exposed to bisphenol A or ethinyl estradiol. There is also a variant on the X1 chromosome Crspx. The primary group of transcripts upregulated in the brain of male Amami spiny rat are transcripts encoding zinc finger proteins yellow highlighted area.
Skip to main content. B Biol. Sex determination and sex differentiation in fish: an overview of the genetic, physiological, and environmental influences. Rosenfeld CS 1.
Fish Physiol. The investigators ascribed the results to the fact that Sry transgene upregulated gonadal hormones, and that the results were independent of genetic sex for the brain cells. Cited by: 41 articles PMID: The sex determining genes in fish appear to vary across species, and several sox forms have been implicated in governing sexual differentiation in diverse fish species Ito et al.
Molecular mechanism of male differentiation is conserved in the SRY-absent mammal, Tokudaia osimensis.